منابع مشابه
VEGF and Tumor Angiogenesis
Based on successful preclinical data, over twenty antiangiogenic agents, alone or in combination with conventional therapies, are now in clinical trial. In the year 2000, close to 1,000 manuscripts describing the basic molecular and cellular mechanisms that allow for an angiogenic response have been published. The goal of this review is to summarize the reasons that angiogenesis re s e a rch ha...
متن کاملVEGF receptor trafficking in angiogenesis.
The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation. The major pro-angiogenic growth factor receptor is VEGFR2 (vascular endothelial growth factor 2). VEGFR2 activates a very similar set of signalli...
متن کاملTherapeutic angiogenesis.
Therapeutic angiogenesis constitutes a fundamental survival mechanism that acts to preserve the integrity of tissues subjected to ischemia. Supplemental administration of angiogenic cytokines--as recombinant protein or plasmid DNA--have been shown to augment collateral development when endogenous angiogenesis is suboptimal for organ function, and thus constitute a novel therapeutic option for t...
متن کاملTherapeutic Angiogenesis
Vascular endothelial growth factor (VEGF) is a heparin-binding, endothelial cell-specific mitogen. Previous studies have suggested thatVEGF is a regulator ofnaturally occurring physiologic and pathologic angiogenesis. In this study we investigated the hypothesis that the angiogenic potential of VEGF is sufficient to constitute a therapeutic effect. The soluble 165amino acid isoform ofVEGF was a...
متن کاملBlockage of VEGF-induced angiogenesis by preventing VEGF secretion.
Vascular endothelial growth factor (VEGF)/vascular permeability factor is one of the most frequently expressed angiogenic factors in several pathological tissues. Development of VEGF antagonists has become an important approach in the treatment of angiogenesis-dependent diseases. Here we describe a novel anti-VEGF strategy by preventing the secretion of VEGF. We utilize the fact that placenta g...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 2000
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.27.3_65